Funding new frontiers in research

Six research projects at Queen’s have received funding from the New Frontiers in Research Fund’s (NFRF) 2020 Exploration competition, a program that encourages scholars to take risks, and that fosters discoveries and innovations that could have significant impacts on our world.

Queen’s researchers will receive $1.5 million ($250,000 per project) from the fund to advance interdisciplinary projects with multiple partners and collaborators. Nationally, the NFRF competition will provide $14.5 million in grants to researchers across Canada, funding 117 projects.

The Exploration competition results will support a wide range of research projects at the university, from creating interactive museum artifacts using digital fabrication methods to breakthroughs in brain injury therapy. Listed below are the funded projects:

• With growing demand for cost-efficient and environmentally-friendly energy sources, nuclear energy may be a viable option to power both remote and on-grid communities. Small modular reactors (SMR) are scaled-down, flexible models of traditional nuclear plants, and many models rely on molten salts to transport thermal energy created by nuclear fission. However, materials performance in molten salt environments is poorly studied. Mark Daymond (Mechanical and Materials Engineering), Suraj Persaud (Mechanical and Materials Engineering), and collaborators will lead experiments evaluating materials in molten salts in the presence of radiation, a breakthrough for implementation of SMR technology globally.
   
• Debate rages as Kingston struggles with the legacy of its most famous former resident, Sir John A. Macdonald, and his actions against Indigenous peoples whose lands and children were taken. Like communities worldwide, the city is at a historic juncture confronting cultural narratives of racism and dispossession. An interdisciplinary team led by Christine Sypnowich (Philosophy) will examine Kingston as a case study to address the social exclusion and historical trauma inherent in current understandings of heritage. Uniting conceptual investigation, health care practice, and cultural resurgence, the team of Indigenous and settler scholars will consider how community-based art practices can contribute to an inclusive heritage and help enable restorative healing for Indigenous and racialized people.
   
• Pharmaceuticals have become contaminants of emerging concern through increased presence in the environment through wastewater, causing great risk to ecosystems and human health. A contributor to this issue is wastewater treatment facilities that are unable to eliminate pharmaceutical ingredients and excreted drug metabolites through their operating systems. Bas Vriens (Geological Sciences and Geological Engineering) and Martin Petkovich (Biomedical and Molecular Sciences) aim to develop new technology that will act as a 'mega-liver', filtering out harmful pharmaceuticals in wastewater treatment facilities in a cost-efficient way to help ensure good health for our communities and environment.
   
• R. David Andrew (Biomedical and Molecular Sciences) is investigating the molecular mechanisms that lead to electrical failure and constriction of blood vessels, a process called spreading depolarization, caused by brain injury. By identifying these mechanisms, the research collaborators will challenge previous knowledge about brain injury therapy and treatments, and propose a method that may prevent loss of brain cells by blocking spreading depolarization, effectively reducing brain damage.
   
• COVID-19 restrictions have brought about innovative ways to engage in cultural experiences virtually. Leveraging digital fabrication methods, such as 3-D scanning and printing, e-textiles and laser cutting, Sara Nabil (School of Computing) and collaborators will demonstrate how human-computer interaction can expand and enrich interactions with museum collections. The team will develop digital fabrication methods that resemble, complement, or augment traditional art. This breakthrough will make the museum experience more widely available to people with disabilities, those living in remote communities, those impacted by COVID-19 lockdowns and more.
   
• Tumours that arise throughout the body called neuroendocrine neoplasms (NENs) cause metastatic disease in up to 50 per cent of patients, giving those diagnosed months to years to survive. However, the molecular basis of highly variable clinical outcomes is poorly understood. Neil Renwick (Pathology and Molecular Medicine), Kathrin Tyryshkin (School of Computing) and collaborators have proposed a radical new way to investigate NENs. The researchers propose using graph neural network models, typically used in computer science, to investigate the gene networks that drive or mediate tumor aggressiveness. The understanding of these molecular social networks may improve accurate knowledge of tumour behaviour and even treatment response, improving NEN clinical outcomes.

The NFRF’s Exploration competition supports research that defies current paradigms, bridges disciplines, or tackles fundamental problems from new perspectives. A key principle of this stream is the recognition that exploring new directions in research carries risk but that these risks are worthwhile, given their potential for significant impact.

“With the support of the NFRF, Queen’s researchers are bringing new ideas and methodologies to critical issues from wastewater treatment to rethinking cultural narratives,” say Kimberly Woodhouse, Vice-Principal (Research). “The potential impact and application of this work will be enhanced and advanced through collaborations that cross disciplinary boundaries.”

The NFRF is an initiative created by the Canada Research Coordinating Committee. It is managed by a tri-agency program on behalf of the Canadian Institutes of Health Research, the Social Sciences and Humanities Research Council, and the Natural Sciences and Engineering Research Council. To find out more, visit the website.

The story was originally published in the Gazette.