COVID-19, the second pandemic of the current century, is still an ongoing global health emergency. Its complications and mortality are associated with pneumonia and alterations in the pulmonary vasculature. Acquiring 3D images of vascular trees in animal models provide a useful tool to evaluate the effects of COVID-19 in humans. In our research aimed at finding new drugs for COVID-19 under the supervision of Dr. Stephen Archer, vascular trees of a mouse were pressure perfused to maximal dilation with a radio-opaque material (barium). The heart and lungs were fixed and scanned using VECTor4CT scanner. VECTor4CT is the first tri-modality imaging system equipped with an ultra-high-resolution micro-computed tomography (µCT) scanner at Queen’s University.