Queen's 2015 Nobel Prize in Physics
Anna Panchenko
Professor (Cross-appointed from Health Sciences)
she/her
Faculty, Medical Physics, Theoretical and Computational Physics
Physics, Engineering Physics & Astronomy
Arts & Science
Prof. Panchenko has openings for new graduate students. Please contact via email.
See Applicants for how to apply.
Research Interests
Our computational biophysics team leverages molecular modelling, molecular dynamics simulations and machine learning techniques to decipher molecular mechanisms of chromatin function. We work in close collaboration with experimental groups and develop integrative approaches that use experimental data - ranging from hydroxyl radical footprinting, chemical crosslinking to cryo-electron microscopy - to guide us in molecular modeling and simulations.
Prof. Panchenko's Social Media
Prof. Panchenko's lab group.
Selected Publications
- Yosef Masoudi-Sobhanzadeh, Shuxiang Li, Yunhui Peng, Anna R. Panchenko, Interpretable deep residual network uncovers nucleosome positioning and associated features, Nucleic Acids Research, Vol 52 Issue 15 (2024)
- Shuxiang Li, Tiejun Wei, Anna R. Panchenko, Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility, Nature Communications, 14 (2023)
- Shuxiang Li, Yunhui Peng, David Landsman, Anna R. Panchenko, DNA methylation cues in nucleosome geometry, stability and unwrapping, Nucleic Acids Research, Vol 50 Issue 4 (2022)
- Yunhui Peng, Shuxiang Li, Alexey Onufriev, David Landsman, Anna R. Panchenko, Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tails, Nature Communications, 12 (2021)