Supramolecular chemistry leverages non-covalent interactions to guide the assembly of small building blocks and manipulate the properties of their resulting macromolecular structures. Among these, σ-hole interactions represent an underexplored domain. These interactions emerge between heavy main group elements from groups 14-18 (Tetrel (Tt), Pnictogen (Pn), Chalcogen (Ch), and Halogen (X)) and electron-rich molecules (Lewis Bases). The remarkable feature of these interactions lies in their ability to be finely tuned through strategic selection of different main group elements, allowing precise control over their strength and directionality.
The Lucia Lee Lab adopts a comprehensive approach to investigating these interactions, employing both organic and inorganic chemistry techniques to synthesize diverse building blocks capable of forming σ-hole interactions. The research focus extends beyond pure academic curiosity, targeting practical applications in sustainable chemistry and chemical biology.
Lab members receive extensive training across multiple scientific domains. They develop expertise in synthetic chemistry methodologies, mastering organic and inorganic synthesis techniques. Simultaneously, they become proficient in advanced characterization methods, including multidimensional nuclear magnetic resonance spectroscopy, ultraviolet-visible and infrared spectroscopy, Raman spectroscopy, and X-ray crystallography. Complementing these experimental skills, the team also conducts sophisticated computational studies using the Amsterdam Modeling Suite, enabling a holistic understanding of molecular interactions and behaviors.