Published
by Springer (January 2011)
A
substantial revision of the first edition (2006)
Books on bioinformatics
began appearing in the mid 80s and primarily served gene-hunters, and
biologists who wished to construct family trees showing tidy lines of
descent. Given the great pharmaceutical industry interest in genes, this
trend has continued in most subsequent texts. These deal extensively
with the exciting topic of gene discovery and searching databases, but
hardly consider genomes as information channels through which multiple
forms and levels of information, including genic information, have
passed through the generations.
This book identifies the types of
information that genomes transmit, shows how competition between
different types is resolved in the genomes of different organisms, and
identifies the evolutionary forces involved. The early chapters relate
the form of information with which we are most familiar, namely written
texts, to the DNA text that is our genome. This lends itself well to
introducing historical aspects dating back to the nineteenth century.
Second edition revisions include expansion of the section on speciation
and a new section on brain bioinformatics. All sections are
substantially updated. |
Note on Second
Edition |
IX |
Prologue
-
To Select is Not To Preserve
|
XIII-XXIII
|
|
|
|
Chapters |
|
|
Part 1. Information and DNA
|
|
1 |
Memory
- A Phenomenon of Arrangement
|
3 |
2 |
Chargaff's
First Parity Rule
|
27 |
3 |
Information
Levels and Barriers
|
47 |
|
|
|
Part
2. Parity and Non-Parity |
|
4 |
Chargaff's
Second Parity Rule
|
69 |
5 |
Stems
and Loops
|
91 |
6 |
Chargaff's
Cluster Rule
|
111 |
|
|
|
Part
3. Variation and Speciation |
|
7 |
Mutation |
131 |
8 |
Species
Survival and Arrival |
153 |
9 |
The Weak Point |
171 |
10 |
Chargaff's GC Rule |
189 |
11 |
Homostability |
205 |
|
|
|
Part
4. Conflict within Genomes |
|
12 |
Conflict
Resolution
|
221 |
13 |
Exons
and Introns
|
249 |
14 |
Complexity
|
267 |
|
|
|
Part
5. Conflict between Genomes |
|
15 |
Self/Not-Self?
|
295 |
16 |
The
Crowded Cytosol
|
319 |
|
|
|
Part
6. Sex and Error-Correction |
|
17 |
Rebooting
the Genome
|
341 |
18 |
The
Fifth Letter
|
363 |
|
|
|
Part 7.
Information and Mind |
|
19 |
Memory
- What to Arrange
and Where |
377 |
|
|
|
Epilogue
-
To Preserve is Not To Select
|
391 |
|
|
|
Appendix
1 What the Graph Says
|
405 |
Appendix
2 Scoring
Information Potential
|
411 |
Appendix
3 No Line?
|
415 |
|
|
|
Acknowledgements, References and Index |
425-510 |
ISBN:
978-1-4419-7770-0 101 illustrations (17 in
colour)
$172.00
For e-book: (Click Here)
For institutions with access to a Springer eBook package, students can
purchase a black and white softcover edition for $24.95
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|