Valérie Langlois - Adjunct Associate Professor
Research: The presence of endocrine disrupting chemicals in the environment presents a significant challenge for ecosystem health. We are interested in understanding the effects of a variety of contaminants present in the environment, especially in aquatic ecosystems. We address and assess this environmental health issue by combining toxicology, molecular biology (RNA-seq, microarray, RT RT-PCR), histology, comparative endocrinology, biochemistry (enzymatic assays, ELISA) and analytical chemistry (HPLC MS-MS) in our study design. Our current research focuses on i) the crosstalk between the thyroid hormone and the androgen axes; ii) the testosterone degradation pathway; and the effects of industrial dyes and plastizers on development and reproduction, especially in amphibians. An important intent of our research program is to train a highly qualified group of science and research professionals in molecular physiology and endocrine disruption research in Canada, two research fields of critical importance in upcoming years.
Lab Website »« email: valerie.Langlois@rmc.ca »« telephone: 613-533-6000 xx77024 ««
Some Recent Publications:
- Denyes MJ, Langlois VS, Rutter A and BA Zeeb. The use of biochar to reduce soil PCB bioavailability to Cucurbita pepo and Eisenia fetida. Sci Total Environ 437:76-82.
- Hayes TB, DeSolla S, Iguchi T2, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, Luque EH, Muñoz-de-Toro M, Oka T, Oliveira CA, Suzawa M, Tillit D, Trudeau VL, Victor-Costa AB and E Willingham (2011) Demasculinization and feminization of male gonads by atrazine: Consistent effects across vertebrate classes. J Steroid Biochem Mol Biol 127:64-73.
- Langlois VS, Rutter A and BA Zeeb (2011) Activated carbon immobilizes residual polychlorinated biphenyls (PCBs) at contaminated terrestrial sites. J Environ Qual 40:1130-4.
- Langlois VS, Duarte-Guterman P and VL Trudeau (2011) Expression profiles of reproduction- and thyroid-related transcripts in the brains of chemically-induced intersex frogs. Sex Dev 5:26-32.
- Mennigen JA, Lado WE, Zamora JM, Duarte-Guterman P, Langlois VS, Metcalfe CD, Chang JP, Moon TW and VL Trudeau (2010) Fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratus. Aquat Toxicol 100:354-64.
- Langlois VS, Zhang D, Cooke GM and VL Trudeau (2010) Evolution of steroid 5-alpha-reductases and a comparison of their function with 5-beta-reductase. Gen Comp Endocrinol. 166:489-97.
- Langlois VS, Carew AC, Pauli BD, Wade MG, Cooke GM and VL Trudeau (2010) Low levels of the herbicide atrazine disrupt Rana pipiens gonadal development and metamorphosis in outdoor mesocosms. Environ Health Perspect 118:552-7.
- Langlois VS, Duarte-Guterman P, Ing S, Pauli BD, Cooke GM and VL Trudeau (2010) Fadrozole and finasteride exposures modulate sex steroid- and thyroid-related gene expression in Silurana (Xenopus) tropicalis early larval development. Gen Comp Endocrinol 166:417-427.
- Zhang D, Duarte-Guterman P, Langlois VS and VL Trudeau (2010) Temporal expression and steroidal regulation of piRNA pathway genes (mael, piwi, vasa) during Silurana (Xenopus) tropicalis embryogenesis and early larval development Comp Biochem Physiol C Tox Pharmacol 152:202-6.
- Duarte-Guterman P, Langlois VS, Pauli BD and VL Trudeau (2010) Expression and T3 regulation of thyroid- and sex steroid-related genes during Silurana (Xenopus) tropicalis early development. Gen Comp Endocrinol 166:428-435.